The chronic toxicity of diphenylamine for dogs.

Jmrn 0. THOMAs, WrLLIA~I E. RrnELIN, 1 JAMES R. WooDWARD, AND FLOYD DEEDs Western Regional Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Albany, California 94710 Receiced .April 28, 1967 When properly used, diphenylamine (DPA) prevents apple scald to a high degree, yet only minute residues of the compound ( <8 ppm) remain on and in the treated fruit (Harvey and Clark, 1959; Bache et al., 1962; Padfield and Clark, 1963). Two-year continued feedings of DPA to albino rats by Thomas et al. ( 1967) revealed no evidence of toxicity until the dietary level of 0.1% was reached. The results of similar experiments with cogs are reported below .